Schedule from the FDA prescribing information for Wegovy (semaglutide for weight management). Weeks are the label's 4-week steps; prescribers may hold a step for longer.
Semaglutide titration schedule in U-100 units
| DoseWeeks | 2 mg + 1 mL2 mg/mL | 5 mg + 2 mL2.5 mg/mL | 10 mg + 2 mL5 mg/mL |
|---|---|---|---|
| 250 mcgWeeks 1–4 | 12.5 u(0.13 mL)8 per vial | 10 u(0.1 mL)20 per vial | 5 u(0.05 mL)40 per vial |
| 500 mcgWeeks 5–8 | 25 u(0.25 mL)4 per vial | 20 u(0.2 mL)10 per vial | 10 u(0.1 mL)20 per vial |
| 1 mgWeeks 9–12 | 50 u(0.5 mL)2 per vial | 40 u(0.4 mL)5 per vial | 20 u(0.2 mL)10 per vial |
| 1.7 mgWeeks 13–16 | 85 u(0.85 mL)1 per vial | 68 u(0.68 mL)2 per vial | 34 u(0.34 mL)5 per vial |
| 2.4 mgWeek 17 on | 120 u(1.2 mL)<1 per vial · over 1 mL | 96 u(0.96 mL)2 per vial | 48 u(0.48 mL)4 per vial |
Swipe the table to see every vial →
Educational reference only — not a dose recommendation. Units assume a U-100 insulin syringe (100 units = 1 mL on U-100); “per vial” is how many of that dose the vial holds, before the small dead-space loss on each draw. Confirm against your own vial, diluent, and clinician or pharmacy instructions.
- Starting dose
- 0.25 mg weekly
- Steps
- Every 4 weeks
- Maintenance (Wegovy)
- 2.4 mg weekly
- Last reviewed
How to read the semaglutide dosage chart
Each row is one step of the Wegovy titration and each column is a common compounded vial set-up. The cell shows the units to draw on a U-100 insulin syringe, the dose in mL, and how many of those doses the vial holds. Semaglutide doses are small, so the units are small too — which is why the FDA has warned about dosing errors with compounded vials, where people confuse mg, mL and units.
Always convert the milligram dose for your own vial. 0.25 mg is 10 units from a 5 mg vial in 2 mL, but 5 units from a 10 mg vial in 2 mL and 12.5 units from a 2 mg vial in 1 mL.
- 5 mg + 2 mL = 2.5 mg/mL → 0.25 mg = 0.1 mL = 10 units
- 10 mg + 2 mL = 5 mg/mL → 0.25 mg = 0.05 mL = 5 units
- 2 mg + 1 mL = 2 mg/mL → 0.25 mg = 0.125 mL = 12.5 units
See also: Semaglutide reconstitution calculator
The Ozempic (type 2 diabetes) schedule in units
Ozempic uses a shorter ladder: 0.25 mg for 4 weeks, then 0.5 mg, with optional increases to 1 mg and then 2 mg after at least 4 weeks on each dose if more glucose control is needed. The maximum is 2 mg a week, below Wegovy's 2.4 mg.
Ozempic semaglutide schedule in U-100 units
| DoseStep | 5 mg + 2 mL2.5 mg/mL | 10 mg + 2 mL5 mg/mL |
|---|---|---|
| 250 mcgWeeks 1–4 | 10 u(0.1 mL)20 per vial | 5 u(0.05 mL)40 per vial |
| 500 mcgWeek 5 on | 20 u(0.2 mL)10 per vial | 10 u(0.1 mL)20 per vial |
| 1 mgIf needed, 4+ weeks later | 40 u(0.4 mL)5 per vial | 20 u(0.2 mL)10 per vial |
| 2 mgIf needed, 4+ weeks later | 80 u(0.8 mL)2 per vial | 40 u(0.4 mL)5 per vial |
Swipe the table to see every vial →
Educational reference only — not a dose recommendation. Units assume a U-100 insulin syringe (100 units = 1 mL on U-100); “per vial” is how many of that dose the vial holds, before the small dead-space loss on each draw. Confirm against your own vial, diluent, and clinician or pharmacy instructions.
See also: Ozempic dosing · Wegovy dosing
How long a semaglutide vial lasts at each step
At the starting dose a vial goes a long way: a 5 mg vial holds twenty 0.25 mg doses, which is far longer than most reconstituted beyond-use dates. Near maintenance the same vial holds only two 2.4 mg doses. Many people choose a smaller vial for the first steps and a larger one later.
- 2 mg vial: 8 doses at 0.25 mg, 4 at 0.5 mg, 2 at 1 mg
- 5 mg vial: 20 doses at 0.25 mg, 5 at 1 mg, 2 at 2.4 mg
- 10 mg vial: 40 doses at 0.25 mg, 10 at 1 mg, 4 at 2.4 mg
Smaller steps and microdosing
Some prescribers hold a step for longer or use doses between the label steps, often described as microdosing, to manage side effects. The label does not describe those schedules, so they are not in this chart. Enter any dose you have been given in the calculator above to get the units for your vial.
Frequently asked questions
What is the semaglutide dosing schedule?
How many units is 0.25 mg of semaglutide?
How many units is 0.5 mg of semaglutide?
How many units is 2.4 mg of semaglutide?
What is the maximum semaglutide dose?
Primary sources
The schedules on this page come from these documents. PepSync converts them into units; it does not recommend a dose.