Quick math example
A 10 mg vial mixed with 2 mL gives 5 mg/mL. A 5 mg dose is 1.0 mL, which equals 100 units on a U-100 syringe.
Reconstitution reference
U100 units to draw for each common MOTS-c dose, by vial size, reconstituted with 2 mL of bacteriostatic water. Change the water volume in the calculator above to recompute for your own setup.
| Vial | Concentration | 2.5 mg | 5 mg | 10 mg |
|---|---|---|---|---|
| 5 mg | 2.5 mg/mL | 100 u(1 mL) | 200 u(2 mL) | 400 u(4 mL) |
| 10 mg | 5 mg/mL | 50 u(0.5 mL) | 100 u(1 mL) | 200 u(2 mL) |
Educational reference only — not a dose recommendation. Units assume a U100 insulin syringe (100 units = 1 mL on U-100). Always confirm against your own vial, diluent, and clinician or pharmacy instructions.
How the MOTS-c calculation works
MOTS-c is typically labelled in milligrams per vial. The calculator first divides the vial mg amount by your BAC water volume to find concentration, then divides your target dose by that concentration.
Once concentration is known, every dose becomes target mg divided by mg per mL.
- 10 mg vial = 10,000 mcg total
- 10,000 mcg / 2 mL = 5,000 mcg per mL
- 5,000 mcg target = 1.0 mL draw
MOTS-c 10 mg vial with 2 mL example
A 10 mg MOTS-c vial mixed with 2 mL gives 5 mg/mL, or 5,000 mcg/mL.
A 5 mg dose is 5,000 mcg, which at this concentration is a full 1.0 mL — 100 units, the entire length of a standard 1 mL U-100 syringe. A 2.5 mg dose would be half that: 0.5 mL, or 50 units.
- 10 mg / 2 mL = 5 mg/mL
- 5 mg / 5 mg per mL = 1.0 mL = 100 U-100 units
- 2.5 mg / 5 mg per mL = 0.5 mL = 50 U-100 units
Reduce the draw with less water or a stronger vial
Because MOTS-c doses are in the multi-milligram range, a dilute vial can push a single dose to the full syringe. Reconstituting with less water raises the concentration and shrinks the draw.
The same 10 mg vial in 1 mL gives 10 mg/mL, so a 5 mg dose drops to 0.5 mL (50 units) instead of a full mL. Always enter your actual figures so the units match your setup.
- 10 mg / 1 mL = 10 mg/mL, so a 5 mg dose = 0.5 mL = 50 units
- Less BAC water = higher concentration = smaller draw
- Keep the draw within your syringe's capacity
Frequently asked questions
Is MOTS-c approved as a medicine?+
Why does my MOTS-c draw volume look large?+
Can a MOTS-c dose exceed my syringe capacity?+
Can PepSync save a MOTS-c protocol?+
Primary sources
Full reference listBackground references for this calculator. PepSync does not make clinical claims; these citations support the educational context only.
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- 2Handling and Storage Guidelines for PeptidesBachem · 2024