Semaglutide reconstitution & dosage calculator

How the semaglutide calculation works

The calculator first converts the vial amount from mg to mcg, then divides by the BAC water volume to find concentration. Your target dose is divided by that concentration to return mL and syringe units.

For GLP-1 compounds, small dose changes can meaningfully change the draw volume. Re-run the calculation whenever vial size, water amount, syringe type, or target dose changes.

• Concentration = vial mcg / water mL
• Dose volume = target dose mcg / concentration
• U-100 units = dose volume mL x 100

Semaglutide 2 mg vial examples

A 2 mg vial in 1 mL gives 2 mg/mL (2,000 mcg/mL). A 0.25 mg dose is 0.125 mL, about 12–13 units; a 0.5 mg dose is 0.25 mL (25 units).

A 2 mg vial covers early titration only. As the dose increases it empties quickly, so most people move to a 5 or 10 mg vial once they pass the starting steps.

• 2 mg / 1 mL = 2 mg/mL → 0.25 mg = ~12.5 units
• 2 mg / 2 mL = 1 mg/mL → 0.25 mg = 0.25 mL = 25 units
• A 2 mg vial yields about eight 0.25 mg doses

Semaglutide 5 mg vial with 2 mL example

A 5 mg semaglutide vial mixed with 2 mL gives a concentration of 2.5 mg/mL, or 2,500 mcg/mL.

A 0.25 mg dose is 250 mcg. At 2,500 mcg/mL, that dose is 0.1 mL, which equals 10 units on a U-100 syringe.

• 5 mg / 2 mL = 2.5 mg/mL
• 0.25 mg = 250 mcg
• 250 mcg / 2,500 mcg per mL = 0.1 mL = 10 U-100 units

Semaglutide 10 mg vial with 2 mL example

A 10 mg semaglutide vial mixed with 2 mL gives a concentration of 5 mg/mL, or 5,000 mcg/mL.

A 0.5 mg dose is 500 mcg. At 5,000 mcg/mL, that dose is 0.1 mL, which equals 10 U-100 units.

• 10 mg / 2 mL = 5 mg/mL
• 0.5 mg = 500 mcg
• 500 mcg / 5,000 mcg per mL = 0.1 mL = 10 U-100 units

Semaglutide dose-to-units chart (5 mg vial in 2 mL)

With a 5 mg vial reconstituted in 2 mL (2.5 mg/mL, or 2,500 mcg/mL), the standard titration doses fall on the unit marks below. At this concentration every 0.25 mg of dose is 0.1 mL, which is 10 units on a U-100 syringe.

This chart is for the 5 mg / 2 mL setup only. A different vial size or water volume changes the concentration and the units — enter your own figures in the calculator to regenerate them.

• 0.25 mg = 0.10 mL = 10 units
• 0.5 mg = 0.20 mL = 20 units
• 1.0 mg = 0.40 mL = 40 units
• 1.7 mg = 0.68 mL = 68 units
• 2.4 mg = 0.96 mL = 96 units

How much BAC water for semaglutide

The water you add sets the concentration; the dose decides the draw. For a 5 mg vial: 1 mL gives 5 mg/mL (0.25 mg = 5 units), 2 mL gives 2.5 mg/mL (0.25 mg = 10 units), and 3 mL gives 1.67 mg/mL (0.25 mg = 15 units).

More water makes small doses easier to measure accurately, because the draw lands on more unit lines. Choose the volume up front for your whole titration rather than topping up a vial that is already mixed.

• 5 mg / 1 mL = 5 mg/mL → 0.25 mg = 5 units
• 5 mg / 2 mL = 2.5 mg/mL → 0.25 mg = 10 units
• 5 mg / 3 mL = 1.67 mg/mL → 0.25 mg = 15 units

Use with compounded or lyophilized vials

This page is intended for situations where you need to calculate a dose from a vial and diluent volume. Pre-filled commercial pens usually do not require this math.

Follow the label, pharmacy directions, and clinician instructions for storage, titration, and beyond-use dates.